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Synthia is alive … and breeding
f="http://www.etcgroup.org">www.etcgroup.org

As Craig Venter announces lab-made life, ETC Group calls for Global
Moratorium on Synthetic Biology.

In a paper published today in the journal Science, the J. Craig Venter
Institute and Synthetic Genomics Inc announced the laboratory creation of
the world's first self-reproducing organism whose entire genome was built
from scratch by a machine.(1) The construction of this synthetic organism,
anticipated and dubbed "Synthia" by the ETC Group three years ago, will
stir a firestorm of controversy over the ethics of building artificial life
and the implications of the largely unknown field of synthetic biology.

Panacea, or...? According to today’s publication, "Synthia" could be a boon
to second-generation agrofuels making it – theoretically – possible to feed
people and cars simultaneously. The article further suggests that Synthia,
or synthetic biology, could help clean up the environment, save us from
climate change, and address the food crisis. "Synthia is not a
one-stop-shop for all our societal woes," disputes Pat Mooney, Executive
Director of ETC Group, an international technology watchdog based in
Canada. “It is much more likely to cause a whole new set of problems
governments and society are ill-prepared to address."

Pandora's Box? "This is the quintessential Pandora’s box moment - like the
splitting of the atom or the cloning of Dolly the sheep. We will all have
to deal with the fall-out from this alarming experiment," comments Jim
Thomas of the ETC Group. "Synthetic biology is a high-risk profit-driven
field, building organisms out of parts that are still poorly understood.(2)
We know that lab-created life-forms can escape, become biological weapons,
and that their use threatens existing natural biodiversity. Most worrying
of all, Craig Venter is handing this powerful technology to the world’s
most irresponsible and environmentally damaging industry by partnering with
the likes of BP and Exxon to hasten the commercialization of synthetic
life-forms."(3)

Synthetic biology refers to the construction of novel life-forms using
synthetic DNA made from off-the-shelf chemicals - a form of "extreme
genetic engineering". The team behind today’s announcement, led by
controversial scientist and entrepreneur Craig Venter, is associated with a
private company, Synthetic Genomics Inc, bankrolled by the US government
and energy behemoths BP and Exxon. Synthetic Genomics recently announced a
$600 million research and investment deal with Exxon Mobil in addition to a
2007 investment from BP for an undisclosed amount. Venter, who led the
private sector part of the human genome project ten years ago, has already
applied for patents related to Synthia's technology.(4)

Although high-profile backers of synthetic biology now occupy key positions
in the US Obama administration(5) there still remains no proper national or
international oversight of new high-risk, technologies that carry vast
implications for humanity and the natural world. In 2006, ETC Group joined
with other organizations to demand the formal, open and inclusive oversight
of synthetic biology(6) and have since called for a global halt on research
pending the development of global regulations. ETC Group has reiterated
that call at a scientific meeting of the United Nations Convention on
Biological Diversity in Nairobi attended by more than 100 governments.(7)

Pandemonium? The lack of global rules governing the field also concerns
many governments, illustrated by the biodiversity talks in Nairobi.
Mundita Lim of the Philippines delegation to the CBD expressed her
country’s concerns "about the serious potential impacts of synthetic
biology on biodiversity... we believe that there should be no field release
of synthetic life, cell or genome into the environment until thorough
scientific assessments have been conducted in a transparent, open and
participatory process involving all Parties, indigenous and local
communities that will all be potentially affected by these synthetic life
forms with unknown consequences on biodiversity, the environment and
livelihoods." Today’s announcement will give new urgency to the debate on
synthetic biology and provide a dramatic example of the need for rigorous
oversight over new technologies before their environmental or commercial
release is permitted.

1) Science, 20 May 2010, "Creation of a Bacterial Cell Controlled by a
Chemically Synthesized Genome," by D. Gibson; J.I. Glass; C. Lartigue; V.N.
Noskov; R.-Y. Chuang; M.A. Algire; M.G. Montague; L. Ma; M.M. Moodie; C.
Merryman; S. Vashee; R. Krishnakumar; N. Assad-Garcia; C.
Andrews-Pfannkoch; E.A. Denisova; L. Young; Z.-Q. Qi; T.H. Segall-Shapiro;
C.H. Calvey; P.P. Parmar; J.C. Venter at J. Craig Venter Institute in
Rockville, MD; G.A. Benders; C.A. Hutchinson III; H.O. Smith; J.C. Venter
at J. Craig Venter Institute in San Diego, CA. The paper acknowledges
'generous funding' from Synthetic Genomics Inc for this work, that three of
the leaders of the scientific team hold executive positions at Synthetic
Genomics Inc and that the J Craig Venter Institute itself holds stock in
Synthetic Genomics Inc.

2) For a graphic overview of the investors behind Synthetic Genomics, Inc,
see ETC Group's 2007 Poster "The Men & Money Behind Synthia." available
here: http://www.syntheticgenomics.com/media/bpfaq.html and reporting of their
deal with Exxon Mobil is available at Dolly...Hello, Synthia! J. Craig Venter Institute Seeks Monopoly Patents on
the World's First-Ever Human-Made Life Form" online at
Synthetic Biology" when he was named to office last year (see

7) ETC Group currently has three staff members in Nairobi at the meeting of
the Subsidiary Body on Scientific, Technical and Technological Advice to
the UN Convention on Biological Diversity (SBSTTA 14). The topic of
synthetic biology is under discussion at SBSTTA 14 under an item concerning
the biodiversity risks of next generation biofuels.

Twitter - ETC Group will be putting out occasional updates on this news
story on Twitter using the hashtag #SYNTHIA - we encourage other to use the
same tag.

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