The Bambisanani Project involves development and implementation of home-based care systems in an area of the Eastern Cape strongly affected by high levels of migrancy-related HIV/AIDS prevalence. The study was conducted in primary (ave. age 13) and high schools (ave. age 18), with the addition of a household survey (ave. age 40) in each of 3 areas. It reports on community responses in terms of a wide range of indicators, and outlines the problems of developing an integrated response to HIV/AIDS in deep rural areas. Recommendations for project implementation, and for monitoring and evaluation are presented in the report.