International Women's Day, focusing this year on the plight of women and HIV/AIDS, carries special significance. In the worst-affected regions of sub-Saharan Africa, women and girls account for 58 percent of those living with HIV/AIDS, and girls age 15-19 are infected at rates four to seven times higher than boys, a disparity linked to sexual abuse, coercion, discrimination, and impoverishment. The Bush administration's new five-year global HIV/AIDS strategy recognizes the urgent situation of women and girls, but much more is needed to translate this into action on the ground.