Antiretroviral treatment significantly reduces the risk of HIV transmission between married couples where one partner is infected and the other is not, according to a recent study in Uganda. The retrospective study, published in the official Journal of the International AIDS Society in February, followed 250 HIV-discordant couples in the central Ugandan district of Rakai between 2004 and 2009. During the study period, 32 HIV-positive partners started ART.